ENAH (gene)

Enabled homolog (Drosophila)

PDB rendering of an EVH1 domain.

Available structures
PDB	2HO2, 2IYB

Identifiers

Symbols

ENAH; ENA; MENA; NDPP1

External IDs

OMIM: 609061 HomoloGene: 84623 GeneCards: ENAH Gene

Gene Ontology
Molecular function	• actin binding • profilin binding • SH3 domain binding • WW domain binding
Cellular component	• stress fiber • cytoplasm • cytosol • cytoskeleton • focal adhesion • lamellipodium • cell junction • filopodium • synapse
Biological process	• neural tube closure • cellular component movement • axon guidance • actin polymerization or depolymerization • intracellular transport • T cell receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_001008493.1

n/a

RefSeq (protein)

NP_001008493.1

n/a

Location (UCSC)

Chr 1:
225.68 – 225.84 Mb

n/a

PubMed search

[1]

n/a

Protein enabled homolog is a protein that in humans is encoded by the ENAH gene.^[1]^[2]

Interactions

ENAH (gene) has been shown to interact with Zyxin^[3]^[4] and ABI1.^[3]

References

^ Sazuka T, Tomooka Y, Kathju S, Ikawa Y, Noda M, Kumar S (Dec 1992). "Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein". Biochim Biophys Acta 1132 (3): 240–8. PMID 1420303.
^ "Entrez Gene: ENAH enabled homolog (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55740.
^ ^a ^b Tani, Katsuko; Sato Seiichi, Sukezane Taiko, Kojima Hiroshi, Hirose Hidenori, Hanafusa Hidesaburo, Shishido Tomoyuki (Jun. 2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase". J. Biol. Chem. (United States) 278 (24): 21685–92. doi:10.1074/jbc.M301447200. ISSN 0021-9258. PMID 12672821.
^ Drees, B; Friederich E, Fradelizi J, Louvard D, Beckerle M C, Golsteyn R M (Jul. 2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins". J. Biol. Chem. (UNITED STATES) 275 (29): 22503–11. doi:10.1074/jbc.M001698200. ISSN 0021-9258. PMID 10801818.

Niebuhr K, Ebel F, Frank R, et al. (1997). "A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family.". Embo J. 16 (17): 5433–44. doi:10.1093/emboj/16.17.5433. PMC 1170174. PMID 9312002. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170174.
Ermekova KS, Zambrano N, Linn H, et al. (1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.". J. Biol. Chem. 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
Mammoto A, Sasaki T, Asakura T, et al. (1998). "Interactions of drebrin and gephyrin with profilin.". Biochem. Biophys. Res. Commun. 243 (1): 86–9. doi:10.1006/bbrc.1997.8068. PMID 9473484.
Geese M, Schlüter K, Rothkegel M, et al. (2000). "Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed.". J. Cell. Sci. 113 ( Pt 8): 1415–26. PMID 10725224.
Krause M, Sechi AS, Konradt M, et al. (2000). "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton.". J. Cell Biol. 149 (1): 181–94. doi:10.1083/jcb.149.1.181. PMC 2175102. PMID 10747096. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2175102.
Drees B, Friederich E, Fradelizi J, et al. (2000). "Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.". J. Biol. Chem. 275 (29): 22503–11. doi:10.1074/jbc.M001698200. PMID 10801818.
Krugmann S, Jordens I, Gevaert K, et al. (2002). "Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex.". Curr. Biol. 11 (21): 1645–55. doi:10.1016/S0960-9822(01)00506-1. PMID 11696321.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading.". J. Cell. Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
Tani K, Sato S, Sukezane T, et al. (2003). "Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.". J. Biol. Chem. 278 (24): 21685–92. doi:10.1074/jbc.M301447200. PMID 12672821.
Garvalov BK, Higgins TE, Sutherland JD, et al. (2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions.". J. Cell Biol. 161 (1): 33–9. doi:10.1083/jcb.200211015. PMC 2172870. PMID 12695497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172870.
Park KW, Morrison CM, Sorensen LK, et al. (2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration.". Dev. Biol. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
Giesemann T, Schwarz G, Nawrotzki R, et al. (2003). "Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and Mena: a possible link to the microfilament system.". J. Neurosci. 23 (23): 8330–9. PMID 12967995.
Salazar MA, Kwiatkowski AV, Pellegrini L, et al. (2004). "Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.". J. Biol. Chem. 278 (49): 49031–43. doi:10.1074/jbc.M308104200. PMID 14506234.
Stüven T, Hartmann E, Görlich D (2003). "Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.". Embo J. 22 (21): 5928–40. doi:10.1093/emboj/cdg565. PMC 275422. PMID 14592989. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=275422.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Di Modugno F, Bronzi G, Scanlan MJ, et al. (2004). "Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response.". Int. J. Cancer 109 (6): 909–18. doi:10.1002/ijc.20094. PMID 15027125.
Tanoue T, Takeichi M (2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact.". J. Cell Biol. 165 (4): 517–28. doi:10.1083/jcb.200403006. PMC 2172355. PMID 15148305. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172355.
Krause M, Leslie JD, Stewart M, et al. (2004). "Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics.". Dev. Cell 7 (4): 571–83. doi:10.1016/j.devcel.2004.07.024. PMID 15469845.

PDB gallery

1evh: EVH1 DOMAIN FROM MURINE ENABLED IN COMPLEX WITH ACTA PEPTIDE

ENAH (gene)

Interactions

References

Further reading